Last edited by Nikole
Tuesday, July 21, 2020 | History

4 edition of Use of Non-human Primates in Drug Evaluation found in the catalog.

Use of Non-human Primates in Drug Evaluation

Harold Vagtborg

Use of Non-human Primates in Drug Evaluation

by Harold Vagtborg

  • 136 Want to read
  • 37 Currently reading

Published by University of Texas Press .
Written in English


The Physical Object
FormatHardcover
Number of Pages456
ID Numbers
Open LibraryOL10294137M
ISBN 100292783744
ISBN 109780292783744

Over the years, drug self-administration procedures in animals have been found to be valid and reliable for determining the abuse liability of drugs in humans. It is well established that animals will self-administer most drugs that are abused by humans [16,17]. In particular, studies in nonhuman primates have made a significant contribution to the field of drug abuse by: The Pocket Handbook of Nonhuman Primate Clinical Medicine is a convenient, concise, case-based handbook written by and for clinicians in charge of the diagnosis and treatment of nonhuman primate patients. Available in both print and electronic formats, this handbook saves readers from having to wade through pages of data and case studies to 5/5(1).

Occupational Health and Safety in the Care and Use of Nonhuman Primates is intended as a reference for vivarium managers, veterinarians, researchers, safety professionals, and others who are involved in developing or implementing an OHSP that deals with nonhuman primates. The book lists the important features of an OHSP and provides the tools.   Only few candidate pharmaceuticals are actually tested on non-human primates (NHPs). Primates are needed to test certain drugs with potential effects on female genital organs, eyes, birth outcomes, blood coagulation, or the brain, as they are the only mammals with specific physiological traits similar to humans.

Animal testing on non-human primates: | | ||| | Two primates in a laboratory cage | | World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled. Review of Research Using Non-Human Primates Effective knowledge transfer from the research laboratory to areas of wider application is a key issue in many areas of science, but is arguably even more pressing when the welfare of sentient creatures has been compromised during the search for improvements in understanding. A key.


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Use of Non-human Primates in Drug Evaluation by Harold Vagtborg Download PDF EPUB FB2

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science.

By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal. The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science.

By covering important topics such as study planning and conduct, inter-species genetic drift. Consequently, newly acquired nonhuman primates should be quarantined for 1–3 months before research use or introduction into established colonies, to permit adequate evaluation of their health status and to allow adaptation to the laboratory or zoo environment.

The directive stresses the use of the 3R principle (replacement, refinement, reduction) and animal welfare when conducting animal testing on non-human primates. A amendment to the German Animal Welfare Act, with special regulations for monkeys, resulted in a near total ban on the use of great apes as laboratory animals.

Title:B-Cells and the Use of Non-Human Primates for Evaluation of HIV Vaccine Candidates VOLUME: 13 ISSUE: 6 Author(s):Thorsten Demberg and Marjorie Robert-Guroff Affiliation:Vaccine Branch, CCR, NCI, NIH, 41 Medlars Drive, Build Room D, Bethesda, MDUSA.

Keywords:B cell development, B cell dysfunction, B cell maturation, Cited by: 3. The Committee on Occupational Health and Safety in the Care and Use of Nonhuman Primates was appointed by the National Research Council (NRC) in response to requests from the National Institutes of Health, the Centers for Disease Control and Prevention, and the Food and Drug Administration to address the risks associated with occupational exposure to nonhuman.

Alternatives to the use of non-human primates (NHPs) in research and testing do exist and can complement but not yet completely replace testing on these primates. As far as possible, the number of animals used should be reduced, methodologies should be refined, and the use of animals should be replaced by alternative methods (3Rs principle).

Abstract. The use of non-human primates in biomedical research is a contentious issue that raises serious ethical and practical concerns. In the European Union, where regulations on their use are very tight, the number of non-human primates used in research has been in decline over the past by: an in-depth study on ‘The use of non-human primates in biological and medical research’.

This will provide a detailed examination of the scientific basis for the use of primates in research. More information is at: PREFACE 6/6/06 am Page IFC2. Introduction. Substance use disorders constitute a class of mental health disorders that pose an insidious public health problem.

For example, an estimated million people worldwide between the ages of 15 to 64 years have used an illicit drug ().Of these users, approximately 10% meet diagnostic criteria for a substance use disorder (American Cited by: 9.

One unique feature to the primate abuse potential studies is that primates are typically reused after drug washout (five or six half-lives) and reestablishing a baseline to conserve animals. Because of their shorter lifespan, rodents are rarely reused for additional drug by: 1.

Non-human primates and drug safety 9 Second species selection in regulatory toxicology 92 Non-human primates, regulatory toxicology and the 3Rs. 95 Discussion 97 9 Alternatives to the use of non-human primates for medical research and toxicology 99 9.

Introduction 99 Molecular and cell biology approaches 99File Size: 2MB. Alternatives to the use of non-human primates in research and testing do exist and can complement but not yet completely replace testing on these far as possible, the number of animals used should be reduced, methodologies should be refined, and the use of animals should be replaced by alternative methods (3Rs principle).

Before pharmaceuticals reach the consumer, their safety has to be tested on humans during clinical trials. Preliminary experiments on animals – often rats and dogs – are intended to protect the health of people taking part in these trials.

Only few candidate pharmaceuticals are actually tested on non-human primates (NHPs). Primates are needed to test certain drugs with. The Use of Nonhuman Primates in Cardiovascular Safety Assessment model using halothane-anesthetized monkeys for evaluation of drug-induced QT interval prolongation.

been documented in non. Notice to Readers: Occupational Safety and Health in the Care and Use of Nonhuman Primates Inthe National Research Council Institute for Laboratory Animal Research (NRCILAR) published the first guide for the management of an Occupational Health and Safety Program (OHSP) for the care and use of laboratory animals (1).This report provided a broad reference.

Since non-human primates share many psychological and biological attributes with humans, most scientists prefer to use them in pharmaceutical experiments.

According to Bailey (), animals are in most cases used to test the effects of a particular drug on the human body as well as testing the drug's nature and chemistry. Use of non-human primates for medical research is misleading, ineffective and harms not only the animals, but also people.

The major use of animals in the medical research is to test the safety of medicine before usage by human beings. evaluation in non-human primates. J Pharmacol T oxicol Methods ; 14– [53] Iizuka H, Sasaki K, Odagiri N, Obo M, Imaizumi M, Atai H. Measurement of r. The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research.

The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management. Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under approach can be contrasted with field studies in which animals are observed in their natural environments or ption: Around 50– million vertebrate .provides accurate and independent information on more t prescription drugs, over-the-counter medicines and natural products.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 4 May ), Cerner Multum™ (updated 4 May .Non-human primates and drug safety the short and longer term and include a re-evaluation of the organisation of non-human.

The use of non-human primates in research and testing. 7.